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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

In addition, a total of 8,035 screens were newly installed last year, at the rate of 22 screens added every day. The total now stands at 31,627 screens.
[i'nili]

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Nine provincial-level regions' GDP exceeded 3 trillion yuan in 2016, three more than the year before. The number of provincial-level areas with GDP surpassing 1 trillion yuan in 2016 remained 25.
胰腺产生胰岛素,如果你的胰腺没有这样做,你需要人工注射胰岛素。因此,糖尿病患者必须进行的日常事例是检查他们的血糖,并且在必要时注射胰岛素。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
From the themed collection: 辛识平:奋斗应提倡 996当退场
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 房企拿地开始“挑挑拣拣”
Open Access Perspective

Soft matter science and the COVID-19 pandemic

After Zhou contaminated the water, one of Zhou's classmates surnamed Tang noticed that the water coming out of the dispenser was milky and had a pungent scent.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

最不守时奖

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

China has fully complied with UN resolutions on the denuclearization of the Korean Peninsula, and is a staunch supporter of upholding the international nuclear non-proliferation regime.
3.卡夫品牌喜爱度:-10%/排名:11
但这种理念不会让英国退欧或者让特朗普当选总统。
1995年,荷兰维和部队未能阻止波黑塞族军队在位于波黑东部的斯雷布雷尼察杀害8000名穆斯林男子和男孩。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

*剧情类最佳客串女演员:玛格?马丁戴尔(Margo Martindale),《美国谍梦》(The Americans)
2016年全球创新指数排名靠前的经济体中,日本、美国、英国、德国在创新质量方面表现突出。
Trium’s alumni value studying alongside senior and international classmates. “It allowed us to exchange [ideas] among ourselves and derive as much additional knowledge as [we gained] from the course itself,” says one.
捷蓝航空公司发言人珍妮·德文(Jenny Dervin)说,“我们75%的航班在东北部起降,无论是纽约还是波士顿,早上航班的延误都可能会影响这架飞机的整条航线。”美国东北部特别容易受到冬季暴风雪的影响,导致航班延误。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

而关于小牛这支球队,问题并不全是司机该怎么让位。在老司机的整个职业生涯中,这一直是一直有实力的球队。德克今年这样支离破碎的赛季实在令人痛苦。或许下个夏天他就会加入科比、KG和大基本功先生的队伍中去。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
From the themed collection: 北京:统筹实施土地资源整理
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

单词pilot 联想记忆:

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

根据QS的这一排名,使得中国成为入选全球400强学校第二多的国家,仅次于有164所大学的学科入选全球400强的美国。英国排名第3,有78所大学进入榜单。
制造业也救不了经济。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

These collaborations signal a moment where the cradle of innovation and the arbiters of fashion are finally embracing one another, says L2 research director Colin Gilbert. Style is not the only missing piece to the wearable puzzle, but it’s something to look forward to, Gilbert says. More than half of the report’s respondents want devices that feel more like jewelry while 62 percent would like more than wrist-worn devices.
周二,她在给客户的一封信里提出了下面几个观点,令我耳目一新:

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

My grandmother’s favorite poem was Invictus by William Ernest Henley. My father hung a copy of it on our kitchen wall, so I grew up reading it every day: “I am the master of my fate; I am the captain of my soul.” I think the best advice I can give anyone – especially someone just starting out in business – is to embrace your role as master of your own fate. Recognize opportunities when they arise and get comfortable saying “Yes.”
与此同时,达洛伊西奥开始环游世界,到处参加会议,并结识其他潜在的投资人。他给每一位结识的人都留下极深的印象。温布尔顿国王学院中学(King’s College School)的校长安德鲁?霍尔斯(Andrew Halls)评价道,他成熟得可怕,他在各种状况下仍保持着清晰的思维,这令我这个54岁的人都觉得惊讶。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Good Time
难怪现代和当代艺术品拍卖市场的主要玩家佳士得拍卖行把自己的早期绘画大师作品重新宣传为“古典艺术品”。它将于明年4月(原先的计划是明年1月)在洛克菲勒中心(Rockefeller Center)举办早期绘画大师作品及其他历史作品拍卖会,其中包括20世纪作品专题拍卖会。周五(12月18日),佳士得称,它的“古典艺术品”拍卖计划将于明年7月在伦敦公布。
去年世锦赛打破男子1500米自由泳世界纪录,孙杨就被认为是中国男子游泳在伦敦实现历史性突破的希望所在。即将开始的伦敦奥运会,孙杨将参加200米、400米和1500米自由泳三项.去年世锦赛孙杨在400米自由泳中不敌朴泰桓屈居亚军,因此他发誓要在伦敦复仇。相比而言,孙杨在1500米的夺金把握更大...
我祖母最喜欢的一首诗是威廉o埃内斯特o亨利的《不可征服》(Invictus)。我父亲把这首诗挂在厨房墙壁上,所以在成长过程中,我每天都会读到它:“我,是我命运的主宰。我,是我灵魂的统帅。”我能为每个人,特别是初入职场者提供的最好建议,就是欣然接受你作为命运主宰的角色。当机会出现时,抓住机会并敢于说“Yes!”

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

动物会根据美感做出选择。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

该协会的首席经济学家Lawrence Yun预计,到今年年底,30年期固息抵押贷款的平均利率将触及5.5%,高于去年底的4.5%和去年上半年的3.5%。抵押贷款利率在短期内如此急剧上升,可能会损害购房者的承受能力,甚至吓退更多购房者。
You'd probably never think that a belt could be integrated with artificial intelligence, yet Belty managed to do it and make it seem stylish. The Beltyautomatically makes you think, "why do I need this?" Then your second thought will probably be, "what if it's hacked and they make it so tight I can't breathe?" The first question is rational; the second one is far-fetched — but if it makes you think twice about buying this product, that's not a bad thing.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

现在是时候制订新年旅游计划了!有“背包客圣经”之称的《孤独星球》于近日向寻找地美价廉好去处的人们推荐了2017年性价比最高的旅游胜地清单。让我们一起来看看吧。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

First, the companies that gained the most consumer love ...

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
From the themed collection: 公租房违规转租为何屡禁不止
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Will oil finish 2018 above $70 a barrel
Meanwhile, WeChat offers perhaps the greatest potential yet for Tencent to gain overseas users. Forrester analyst Bryan Wang said he has seen colleagues and friends in Singapore and India begin to appear on his WeChat contact list.
Ms Lewis urged people to contact family, neighbours or an animal shelter if they were no longer able to care for their pets.
《出租车司机》被誉为历史上最伟大的电影之一,讲述了一名沮丧的前海军陆战队员,在被爱慕的女子拒绝后,试图暗杀参议员的故事。名义上的出租车司机崔维斯·拜寇,生活混乱,充斥着毒贩和妓女,但他的故事从来不是不现实的幻想。相反,它揭示了一个人差点成为成为枪手的真实预警。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

According to the search engine, Euro 2012 beat Olympics tickets as the top internet search of the year in the UK, the Sun reported.
This is the moment hundreds of lovestruck Irish football fans gathered around a blonde French girl and serenaded her - and one admirer even stole a kiss from the woman at the end.
8)让我想想:是的,这话听起来有点像托词。有时,它就是托词。事实是,我们不可能任何时候都有权或有资格做决策。这句话为你赢得了思考的时间,你大可喘口气。然后,设定好日期及具体时间,做好跟进工作,让对方知道你很在乎他。
以丹麦为例,如今,88%的丹麦人口都是白人——这样的多数地位很难动摇。但在1980年,也就是上一代人的时候,丹麦有97%的人口是白人。反移民的丹麦人民党(Danish People’s Party)现在是丹麦议会中的第二大党。在德国,从2011年到2015年间,非本土出生人口激增了大约75%,反移民的民粹政党德国另类选择党(Alternative for Germany)如今获得了破纪录的支持率。
Insecure

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

谷歌和亚马逊分居第二、三名。
尽管可以下载的课程具有较好前景,但在现实世界,得到官方承认的学历仍然基于课堂教学活动。初创公司采取了这样一种态度:如果他们无法以新的服务交付方式在高校的地盘上击败它们,那就应该与之建立合作伙伴关系。其结果是,他们忙着争取考试委员会核准他们的在线课程,使其可以算作学士或硕士学位资格的一部分。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

11月,由财新网(Caixin)赞助的中国制造业采购经理人指数(PMI)初值为48.6,高于预期的48.3。而10月份该读数则为48.3。读数显示上个月中国制造业活动在继续放缓,不过情况没有10月份那么糟糕。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Managers are able to reward their subordinates in unique, personalized ways thanks to the budget they receive from corporate. Two examples of past bonuses: free trail rides at an equestrian stadium and a barbeque with lassoing and horseshow throwing lessons.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 沪深两市成交额突破10000亿元
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

据BT下载网站TorrentFreak数据显示,《权力的游戏》每集平均下载人数有590万。这个数字还不包括在线视频和cyberlocker的下载方式,如果算上这种方式,数据将会更高。而《权力的游戏》每一集的平均收视人数才550万。
28 September
The other issue with tanking is Philly, Phoenix, and Brooklyn are all bad teams. It's going to be hard to outflank those outfits.
[sp?n'teini?s]

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

毋庸置疑,改造比创造容易。任何曾经对着白纸一筹莫展的人都知道这一点。但是,在过去七年里,时尚界对60年代的普遍模仿至少暴露出,这个行业缺乏想象力——不只是对于服装和消费者缺乏想象力,而且对于文化与服装的关系也缺乏想象力。
Misrepresenting your credentials or intentionally plagiarizing, lying on time sheets or billable hours, misusing expense accounts or abusing company credit cards, stealing the kudos for a co-workers' accomplishments, or otherwise robbing your employers blind can all cost you your job.
Best Companies rank: 59
美联储去年花了六个多月的时间暗示其有意退出第三轮购债计划,这种可能性时常扰动着市场。目前美联储仅处于退出购债计划的第一阶段。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

1.无叶风扇
根据考试结束后网上发布的考题和部分考生的反馈,今年的考题难度适中,长征火箭、我国外交事务、"玉兔"月球车和大学生创业等政治和社会热点问题都有出现。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

4.嘘声不仅仅是个手势
Yao has been at the center of a hostile takeover battle for China's largest real estate developer China Vanke Co Ltd (000002.SZ).
祝你享尽新年佳节的快乐和新年的礼品。
The husband-and-wife team behind Little Miss Sunshine tackle the 1977 gender war between Bobby Riggs, washed-up 55-year-old tennis pro, and Billie Jean King, the young ace (then No 2 in the world) he challenged to a match.
怎样减肥?

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

It was also the "most liked" tweet of the year, with 4.59 million likes.
我经常觉得不开心
全国而言,价格环比涨幅仅为0.6%,是三个月来涨幅首次低于1%,比9月份2.1%的涨幅高点也低了不少。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

We think of the passage of NBA time in seasons, for obvious reasons. There's connection, a continuum. It's how we remember things that happen, in the course of a season of play. But there's some benefit to looking back at a calendar year, January 1 to December 31, and what we've learned in that process. After all, many say the "unofficial start" to the NBA season is Christmas, with the new year starting soon after. So here are the lessons we learned about the NBA in the year 2017.
When a cup is placed on a dispenser, a magnet lifts to let beer flow in.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

McDonough School of Business at Georgetown University in Washington DC returns to the custom ranking in 15th place after dropping out last year because of a low survey response rate from clients. Only three schools enter the custom ranking for the first time, including London’s Cass Business School in 60th place.
在土耳其问题上,普京表示,他看不到与现任土耳其领导人消除紧张关系的可能性。土耳其不久前击落了一架俄罗斯战机。他说,他非常震惊地看到,土耳其非但没有对其行为做出解释,反而转向北约寻求帮助。
But the declines continued, and now it’s all over, red rover.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

The seven large brick tombs were likelyconstructed for people of wealth, the researchers said.
Chinese direct investment in the eurozone was up 37 per cent in 2015, rising to $17.1bn from $12.5bn.
为了缓解人口过多的问题,科学家研究出一项技术,可以将人缩小到只有5英寸高(12.7cm)。保罗(马特?达蒙饰)和妻子奥德丽(克里斯汀?韦格饰)决定把紧巴巴的生活抛在身后,自愿缩身加入一个全新的迷你社区。这一决定使得这对夫妇的人生发生了翻天覆地的变化。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Russia's economy is the 10th largest in the world, producing little of value beyond hydrocarbons. Corruption and rent-seeking extract an enormous economic toll. It remains burdened with Soviet era infrastructure, and its ability to meet the educational and medical needs of its population is rapidly declining.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

8. Pour-Protection by Pet Life

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

5.卡特彼勒
He Fan, economist at Caixin, said:“This shows that the macro economy has moved further toward stable growth and the economic structure is improving. Future fiscal and monetary policies must be coordinated and large-scale stimulus should be avoided as much as possible.”

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

check原是检查的意思,后来有这么一帮人喜欢突然阻止你,检查你的暂住证,所以就有了突然阻止的意思。
在本届戛纳电影节上,女性电影制作人以及相关女性话题曾广受关注成为宣传主题。28年来,戛纳首次以女导演拍摄的电影拉开序幕,伊莎贝拉?罗西里尼(Isabella Rossellini)成为“一种关注”单元评审团主席,莎尔玛?海雅克(Salma Hayek)主持讨论会高调探讨女性角色在电影中的意义。可以讨论的话题有许多,但是真的有何改变吗?数字似乎更能说明问题,主竞赛单元的19部入围作品仅有2部来自女性导演。而后发生的“高跟鞋门”,更有.....面对外界对于影展涉嫌性别歧视的负面消息,艺术总监蒂埃里?弗雷莫(Thierry Frémaux)一点儿反应都没。他只是说,戛纳电影节的举办有着及其不公平的高标准,参展影片不能申请其他诸如威尼斯或柏林电影节。这难道是建议人们去“攻击奥斯卡”?
要不是朝鲜再次进行核试验,朝鲜半岛眼下的大新闻可能就是特朗普选在这个节骨眼上宣布计划退出韩美贸易协定了。
报告还发现,在“智力资本和创新”及“技术成熟度”等指标方面排名较高的城市综合排名也很高,这很明确地表明,技术上先进的城市更有可能成为“机遇城市”。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

The government needs to work to emancipate and develop productive forces, bring out the initiative for the people and deliver greater benefits to the general public, the essence of governance is to always act in the overall interests of the whole country rather than just acting in one scenario departmental interests. The essence of our government is to always respond to the people’s call.
1. Buy expensive tailored clothing that only sort of fits so that most of the time your buttons appear to be just seconds from bursting.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

2.别迷恋哥,哥只是个传说。
但他们事先计划投放100000反平壤宣传单。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 聚焦:十大新型建材走红国内市场
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

官方数据显示,全年票房过亿元影片共计81部,其中国产影片占47部。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

美国上市交易相比2016年(多年来最疲弱的年份之一)出现起色。根据Dealogic的统计,今年迄今已有112笔IPO得到定价,而去年这个时候只有63笔。发行金额翻了一番多,达到316亿美元。
n. 宪章,特许,(船、机、车等的)租赁
China's actual use of foreign capital during the 2010-2015 period is expected to reach 620 billion USdollars with the tertiary sector taking over 60 percent of total foreign capital. Outbound direct investment grew at 14.2 percent annually.
The night's biggest winners may have been hosts Ms. Fey and Ms. Poehler, whose second time hosting the Hollywood Foreign Press Association's Beverly Hills, Calif., ceremony was just as successful as last year's show (a six-year ratings high with 19.7 million viewers).

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

Another exceptional new field is that of nanotechnology.
n. 争斗,战斗

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

201212/212620.shtmlChina won the Robot World Cup Soccer 2013 against the Netherlands in a thrilling match that resulted in a 2-3 win for China.The Robot World Cup Soccer was held in Eindhoven, the Netherlands, which defended its Robot World Cup title of last year.
7The United States
外套。来一套贝达弗的大衣和蓝围巾。一套价值1350英镑的大衣,随时准备迎接人生的精彩时刻。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

17. 最复杂的障碍。根据Box Office Mojo网站统计,截止到12月7日,今年发行的20部票房最高的影片中,有7部是由女性主导的。与之形成对照的是,20部由女性为主导的影片中,有五部在全球票房领先,而海外票房占据了电影业收入的70%。这看上去可能很糟,但是比近年的数据要好一点。
While D'Aloisio spends 80 percent of his work time retooling and improving Summly (which has already been integrated into Yahoo!'s iPhone app), the other 20 percent is devoted to imagining the expansive challenges he'll take on next. He predicts there will be summarization programs that do for video what Summly does for the written word. He has grand thoughts about using technology to aid learning and would like to help fellow autodidacts while disrupting the old educational models.
虽然香港、悉尼和温哥华地处全球的不同角落,但是它们有着同一个特征。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

学员平均年龄:费城班33岁,旧金山班36岁
茱莉亚哈茨

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 贵州省家居建材商会成立
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Did you write The Lego Batman Movie off as kids-only? Biggest mistake ever. This movie is a witty feat of hilarity, full of dry humor and moments of comedy gold. Basically, if you like Will Arnett in Arrested Development, you will like this.
智能冰箱
creative

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: 多方合力推动新型建材研发
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Game of Thrones
唐同学怀疑水中被混合了有毒物质,便把此事报告给班长和老师。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

romantic
单词elegant 联想记忆:
Disparity between the 34 cities surveyed was still greater, as the the average bonus of over Rmb15,800 in Beijing was more than triple the lowest-paying city of Shenyang, the provincial capital Liaoning located in China’s northeastern rust belt.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

贝恩公司(Bain & Company)也正处于变革之中,去年11月该公司宣布曼尼马塞达(Manny Maceda)将于2018年3月成为其全球领导人,从鲍勃博切克(Bob Bechek)手中接管这家总部位于波士顿的咨询机构;马塞达将是该公司首位亚洲血统的掌门人。专家们表示,马塞达可能推动该公司开拓新的专长领域,并摆脱业务多而不精的名声。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

One might expect that online programmes would appeal proportionately more to women than full-time programmes due to their flexibility. How-ever, data from the 2016 rankings show that women account for 30 per cent of enrolled students compared with 35 per cent for full-time programmes.
英国的一个收集全球气温纪录的科学小组也将在未来几周内提交报告。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

May the New Year bring many good things and rich blessings to you and all those you love!
此外,排名前列的城市的“成本”、“文化与居民生活”两项指标普遍不高。在满足民众需求、并提供高质量生活方面,中国的“机遇城市”仍然面临挑战。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

3.在戛纳,他们说英语
Anyone can have a bad day at the office, but this disappointing performance at Christie’s followed an old masters sale in July that took in 19 million against a low estimate of 31.5 million.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

2005年初,斯通和其联合创始人爱丽莎卡玛赫特和朱瑞德斯贾丁斯发现,使用博客的女性规模庞大,但主流媒体却很少会引用她们的文章。于是,三人决定召开一次草根会议,并吸引了谷歌和雅虎(Yahoo)等赞助商。门票很快销售一空,不久,她们便成立了BlogHer.com。这个博客发布平台把撰写博客变成了许多女性可以用来赚钱的一项业务——2009年至2012年期间,这家公司向5,000名博主支付了超过2,500万美元。目前,这个平台的用户已经超过9,200万人。
In comparison, second-tier cities reported worsening congestion, an increase of 3.7% on average, with Chongqing, Changchun, Jiaxing and Shenyang leading the rate of growth at over 7%.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Best wishes for the holidays and happiness throughout the New Year.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 中国建材行业一周大事记(7.20-7.26)
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

土耳其副总理库尔图尔姆斯说,土耳其当局与伊拉克方面保持着接触。
9.澳大利亚贝拉林半岛
The King’s Woman
For almost everyone else, it was a year of frustration against a backdrop of better-than-average returns for the most popular index in the land.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 这种房子要交税!涉及数亿人
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

尽管小小年纪她的事业就取得了如此惊人的成就,但如果给自己的成就打分,且10分满分的话,玛蒂只给自己打9分。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

This quiet, intense Israeli film unfolds like a psychological thriller. A poetry-loving teacher discovers that one of her young pupils is a literary prodigy, and takes increasingly extreme measures to protect his gift from an indifferent world. As the story unfolds, it becomes clear that Mr. Lapid is engaged in a stealthy, ferocious critique of a society that has sacrificed its spiritual values and its cultural inheritance on the altar of power and materialism.
当城市规划部门明年初(2015年——译注)提出初步的建议方案时,布鲁克林的东纽约(East New York)地区将被列为试点。随后,重新区划进程就将在该处全市最穷社区之一内展开。而紧随其后的,将是针对皇后区的西法拉盛(Flushing)的提案。
0=不是

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 乐居发布“1+1+7”全新业务战略
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

圣加伦大学校友的薪资排名第三,为114449美元(按购买力平价调整后),排在艾哈迈达巴德的印度管理学院(Indian Institute of Management)和印度管理学院班加罗尔分校(IIM Bangalore)之后,这两所商学院校友的平均薪资分别为116476美元和116094美元。圣加伦大学还在职业服务质量方面排名第一。
近日中国警方对南部一家不法食品商家进行突袭,曝光成吨的腐臭鸡爪。这些有几十年历史的“美味”经过“特殊加工”后,会卖给毫不知情的消费者。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

American brands such as Chipotle, Texas Instruments and General Dynamics are on the list for the first time.
图表一显示的是上世纪70年代以来新兴市场银行、汇率及债务违约危机的发生次数——对照名义联邦基金利率。克普克以此为据,试图证明高位且不断上升的利率通常在新兴市场危机爆发周期之前出现。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

If 2017 was the year policymakers began to worry about the growth of the “precariat”, 2018 will be the year they try to do something about it.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: “互联网+”让环保也变得智能化
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Wishing you all the blessings of a beautiful New Year season.愿你拥有新年所有美好的祝福。
遇到别人我能很轻松地和他/她交谈
这个由财新赞助的系列指数,是基于对民营企业的调查得出的,样本数目也比官方PMI指数少得多,往往波动性更大。相比之下,官方PMI指数则主要关注规模更大的国有企业。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

自高中以后,科比就没怎么变过,即便他已经离开劳尔梅里恩高中16年了。
单词muscular 联想记忆:
1. How to make pancakes
According to exam questions and some test-takers' feedback posted online after the exam, the difficulty of the questions was moderate and hot political and social issues, such as the Long March rockets, China's foreign affairs, the Yutu lunar rover and entrepreneurial efforts by college students, were mentioned.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Closer to home, fake official data are just as prevalent. The UK’s Office for National Statistics on Tuesday reported that British inflation, measured by its longstanding retail prices index, rose to 4.1 per cent in December. This number is nonsense and the ONS knows it. It tells people the RPI “does not meet the required standard” to be given a quality stamp, yet it has refused since 2012 to take steps to improve the measure and bring it closer to the lower headline measure of 3 per cent.
Game of Thrones

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

10. Mail carrier
数据还显示,网红的分布和经济发展水平也有密切关系,北京、上海、广东、江苏和浙江等较发达地区是网红分布最多的五个地区。
Russia and Nato have both called for a de-escalation of the Turkey-Netherlands row.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

[.reidi'ein]
和许多评论家一样,我一方面了解清单的便利,一方面也讨厌清单的专横。所以我永远不可能只列出十部――我怎么做得到呢,北美影院一年就要上映900多部影片呢――今年是2015年,所以我挑选了15部,为它们分门别类,计数时做了一点含糊,所以最后其实是20部。其中有两部片名的不代表并列,而是代表有两种特色,可以成对观看,二者的优点相映成趣。

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