Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
In addition, a total of 8,035 screens were newly installed last year, at the rate of 22 screens added every day. The total now stands at 31,627 screens.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nine provincial-level regions' GDP exceeded 3 trillion yuan in 2016, three more than the year before. The number of provincial-level areas with GDP surpassing 1 trillion yuan in 2016 remained 25.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
After Zhou contaminated the water, one of Zhou's classmates surnamed Tang noticed that the water coming out of the dispenser was milky and had a pungent scent.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
China has fully complied with UN resolutions on the denuclearization of the Korean Peninsula, and is a staunch supporter of upholding the international nuclear non-proliferation regime.
Trends and targets in antiviral phototherapy
*剧情类最佳客串女演员：玛格?马丁戴尔(Margo Martindale)，《美国谍梦》(The Americans)
Trium’s alumni value studying alongside senior and international classmates. “It allowed us to exchange [ideas] among ourselves and derive as much additional knowledge as [we gained] from the course itself,” says one.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
These collaborations signal a moment where the cradle of innovation and the arbiters of fashion are finally embracing one another, says L2 research director Colin Gilbert. Style is not the only missing piece to the wearable puzzle, but it’s something to look forward to, Gilbert says. More than half of the report’s respondents want devices that feel more like jewelry while 62 percent would like more than wrist-worn devices.
Diagnostic technologies for COVID-19: a review
My grandmother’s favorite poem was Invictus by William Ernest Henley. My father hung a copy of it on our kitchen wall, so I grew up reading it every day: “I am the master of my fate; I am the captain of my soul.” I think the best advice I can give anyone – especially someone just starting out in business – is to embrace your role as master of your own fate. Recognize opportunities when they arise and get comfortable saying “Yes.”
与此同时，达洛伊西奥开始环游世界，到处参加会议，并结识其他潜在的投资人。他给每一位结识的人都留下极深的印象。温布尔顿国王学院中学(King’s College School)的校长安德鲁?霍尔斯(Andrew Halls)评价道，他成熟得可怕，他在各种状况下仍保持着清晰的思维，这令我这个54岁的人都觉得惊讶。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
You'd probably never think that a belt could be integrated with artificial intelligence, yet Belty managed to do it and make it seem stylish. The Beltyautomatically makes you think, "why do I need this?" Then your second thought will probably be, "what if it's hacked and they make it so tight I can't breathe?" The first question is rational; the second one is far-fetched — but if it makes you think twice about buying this product, that's not a bad thing.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
First, the companies that gained the most consumer love ...
Antiviral drug discovery: broad-spectrum drugs from nature
Will oil finish 2018 above $70 a barrel
Meanwhile, WeChat offers perhaps the greatest potential yet for Tencent to gain overseas users. Forrester analyst Bryan Wang said he has seen colleagues and friends in Singapore and India begin to appear on his WeChat contact list.
Ms Lewis urged people to contact family, neighbours or an animal shelter if they were no longer able to care for their pets.
Influenza neuraminidase: A druggable target for natural products
According to the search engine, Euro 2012 beat Olympics tickets as the top internet search of the year in the UK, the Sun reported.
This is the moment hundreds of lovestruck Irish football fans gathered around a blonde French girl and serenaded her - and one admirer even stole a kiss from the woman at the end.
以丹麦为例，如今，88%的丹麦人口都是白人——这样的多数地位很难动摇。但在1980年，也就是上一代人的时候，丹麦有97%的人口是白人。反移民的丹麦人民党(Danish People’s Party)现在是丹麦议会中的第二大党。在德国，从2011年到2015年间，非本土出生人口激增了大约75%，反移民的民粹政党德国另类选择党(Alternative for Germany)如今获得了破纪录的支持率。
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Managers are able to reward their subordinates in unique, personalized ways thanks to the budget they receive from corporate. Two examples of past bonuses: free trail rides at an equestrian stadium and a barbeque with lassoing and horseshow throwing lessons.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The other issue with tanking is Philly, Phoenix, and Brooklyn are all bad teams. It's going to be hard to outflank those outfits.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Misrepresenting your credentials or intentionally plagiarizing, lying on time sheets or billable hours, misusing expense accounts or abusing company credit cards, stealing the kudos for a co-workers' accomplishments, or otherwise robbing your employers blind can all cost you your job.
Best Companies rank: 59
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Yao has been at the center of a hostile takeover battle for China's largest real estate developer China Vanke Co Ltd (000002.SZ).
The husband-and-wife team behind Little Miss Sunshine tackle the 1977 gender war between Bobby Riggs, washed-up 55-year-old tennis pro, and Billie Jean King, the young ace (then No 2 in the world) he challenged to a match.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
It was also the "most liked" tweet of the year, with 4.59 million likes.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
We think of the passage of NBA time in seasons, for obvious reasons. There's connection, a continuum. It's how we remember things that happen, in the course of a season of play. But there's some benefit to looking back at a calendar year, January 1 to December 31, and what we've learned in that process. After all, many say the "unofficial start" to the NBA season is Christmas, with the new year starting soon after. So here are the lessons we learned about the NBA in the year 2017.
When a cup is placed on a dispenser, a magnet lifts to let beer flow in.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
McDonough School of Business at Georgetown University in Washington DC returns to the custom ranking in 15th place after dropping out last year because of a low survey response rate from clients. Only three schools enter the custom ranking for the first time, including London’s Cass Business School in 60th place.
But the declines continued, and now it’s all over, red rover.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
The seven large brick tombs were likelyconstructed for people of wealth, the researchers said.
Chinese direct investment in the eurozone was up 37 per cent in 2015, rising to $17.1bn from $12.5bn.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Russia's economy is the 10th largest in the world, producing little of value beyond hydrocarbons. Corruption and rent-seeking extract an enormous economic toll. It remains burdened with Soviet era infrastructure, and its ability to meet the educational and medical needs of its population is rapidly declining.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
8. Pour-Protection by Pet Life
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
He Fan, economist at Caixin, said:“This shows that the macro economy has moved further toward stable growth and the economic structure is improving. Future fiscal and monetary policies must be coordinated and large-scale stimulus should be avoided as much as possible.”
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
在本届戛纳电影节上，女性电影制作人以及相关女性话题曾广受关注成为宣传主题。28年来，戛纳首次以女导演拍摄的电影拉开序幕，伊莎贝拉?罗西里尼(Isabella Rossellini)成为“一种关注”单元评审团主席，莎尔玛?海雅克(Salma Hayek)主持讨论会高调探讨女性角色在电影中的意义。可以讨论的话题有许多，但是真的有何改变吗？数字似乎更能说明问题，主竞赛单元的19部入围作品仅有2部来自女性导演。而后发生的“高跟鞋门”，更有.....面对外界对于影展涉嫌性别歧视的负面消息，艺术总监蒂埃里?弗雷莫(Thierry Frémaux)一点儿反应都没。他只是说，戛纳电影节的举办有着及其不公平的高标准，参展影片不能申请其他诸如威尼斯或柏林电影节。这难道是建议人们去“攻击奥斯卡”？
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The government needs to work to emancipate and develop productive forces, bring out the initiative for the people and deliver greater benefits to the general public, the essence of governance is to always act in the overall interests of the whole country rather than just acting in one scenario departmental interests. The essence of our government is to always respond to the people’s call.
1. Buy expensive tailored clothing that only sort of fits so that most of the time your buttons appear to be just seconds from bursting.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
China's actual use of foreign capital during the 2010-2015 period is expected to reach 620 billion USdollars with the tertiary sector taking over 60 percent of total foreign capital. Outbound direct investment grew at 14.2 percent annually.
The night's biggest winners may have been hosts Ms. Fey and Ms. Poehler, whose second time hosting the Hollywood Foreign Press Association's Beverly Hills, Calif., ceremony was just as successful as last year's show (a six-year ratings high with 19.7 million viewers).
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Another exceptional new field is that of nanotechnology.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
201212/212620.shtmlChina won the Robot World Cup Soccer 2013 against the Netherlands in a thrilling match that resulted in a 2-3 win for China.The Robot World Cup Soccer was held in Eindhoven, the Netherlands, which defended its Robot World Cup title of last year.
7The United States
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
17. 最复杂的障碍。根据Box Office Mojo网站统计，截止到12月7日，今年发行的20部票房最高的影片中，有7部是由女性主导的。与之形成对照的是，20部由女性为主导的影片中，有五部在全球票房领先，而海外票房占据了电影业收入的70%。这看上去可能很糟，但是比近年的数据要好一点。
While D'Aloisio spends 80 percent of his work time retooling and improving Summly (which has already been integrated into Yahoo!'s iPhone app), the other 20 percent is devoted to imagining the expansive challenges he'll take on next. He predicts there will be summarization programs that do for video what Summly does for the written word. He has grand thoughts about using technology to aid learning and would like to help fellow autodidacts while disrupting the old educational models.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Did you write The Lego Batman Movie off as kids-only? Biggest mistake ever. This movie is a witty feat of hilarity, full of dry humor and moments of comedy gold. Basically, if you like Will Arnett in Arrested Development, you will like this.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Game of Thrones
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Disparity between the 34 cities surveyed was still greater, as the the average bonus of over Rmb15,800 in Beijing was more than triple the lowest-paying city of Shenyang, the provincial capital Liaoning located in China’s northeastern rust belt.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
贝恩公司(Bain & Company)也正处于变革之中，去年11月该公司宣布曼尼马塞达(Manny Maceda)将于2018年3月成为其全球领导人，从鲍勃博切克(Bob Bechek)手中接管这家总部位于波士顿的咨询机构；马塞达将是该公司首位亚洲血统的掌门人。专家们表示，马塞达可能推动该公司开拓新的专长领域，并摆脱业务多而不精的名声。
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
One might expect that online programmes would appeal proportionately more to women than full-time programmes due to their flexibility. How-ever, data from the 2016 rankings show that women account for 30 per cent of enrolled students compared with 35 per cent for full-time programmes.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
May the New Year bring many good things and rich blessings to you and all those you love!
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Anyone can have a bad day at the office, but this disappointing performance at Christie’s followed an old masters sale in July that took in 19 million against a low estimate of 31.5 million.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
In comparison, second-tier cities reported worsening congestion, an increase of 3.7% on average, with Chongqing, Changchun, Jiaxing and Shenyang leading the rate of growth at over 7%.
A facile assay for rapid detection of COVID-19 antibodies
Best wishes for the holidays and happiness throughout the New Year.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The King’s Woman
For almost everyone else, it was a year of frustration against a backdrop of better-than-average returns for the most popular index in the land.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
This quiet, intense Israeli film unfolds like a psychological thriller. A poetry-loving teacher discovers that one of her young pupils is a literary prodigy, and takes increasingly extreme measures to protect his gift from an indifferent world. As the story unfolds, it becomes clear that Mr. Lapid is engaged in a stealthy, ferocious critique of a society that has sacrificed its spiritual values and its cultural inheritance on the altar of power and materialism.
当城市规划部门明年初（2015年——译注）提出初步的建议方案时，布鲁克林的东纽约(East New York)地区将被列为试点。随后，重新区划进程就将在该处全市最穷社区之一内展开。而紧随其后的，将是针对皇后区的西法拉盛(Flushing)的提案。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
圣加伦大学校友的薪资排名第三，为114449美元（按购买力平价调整后），排在艾哈迈达巴德的印度管理学院(Indian Institute of Management)和印度管理学院班加罗尔分校(IIM Bangalore)之后，这两所商学院校友的平均薪资分别为116476美元和116094美元。圣加伦大学还在职业服务质量方面排名第一。
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
American brands such as Chipotle, Texas Instruments and General Dynamics are on the list for the first time.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
If 2017 was the year policymakers began to worry about the growth of the “precariat”, 2018 will be the year they try to do something about it.
Anti-HIV drug repurposing against SARS-CoV-2
Wishing you all the blessings of a beautiful New Year season.愿你拥有新年所有美好的祝福。
Length-scale dependence of protein hydration-shell density
1. How to make pancakes
According to exam questions and some test-takers' feedback posted online after the exam, the difficulty of the questions was moderate and hot political and social issues, such as the Long March rockets, China's foreign affairs, the Yutu lunar rover and entrepreneurial efforts by college students, were mentioned.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Closer to home, fake official data are just as prevalent. The UK’s Office for National Statistics on Tuesday reported that British inflation, measured by its longstanding retail prices index, rose to 4.1 per cent in December. This number is nonsense and the ONS knows it. It tells people the RPI “does not meet the required standard” to be given a quality stamp, yet it has refused since 2012 to take steps to improve the measure and bring it closer to the lower headline measure of 3 per cent.
Game of Thrones
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
10. Mail carrier
Russia and Nato have both called for a de-escalation of the Turkey-Netherlands row.
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