Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Around 280 million train tickets have been sold on 12306.cn since Jan 3, 2018 when tickets for the Spring Festival holiday started selling.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
But, despite the incessant warnings from security researchers, many people are still turning to weak, easily guessable passwords to protect their devices.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Chinese consumer prices rose in January, an encouraging sign for the world’s second largest economy in a month characterised by turbulence in its financial markets.
年度最佳合唱：埃里克·丘奇、杰森·阿尔丁、卢克布·莱恩《The Only Way I Know》
Trends and targets in antiviral phototherapy
她也曾应邀参加《吉米秀》(Jimmy Kimmel)和《艾伦秀》(The Ellen Show)。对于一个青春期未到的人来说，有机会上这两个节目还算不错。
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Four other domestic movies made it to the top ten list, among them are the third winner Never Say Die, Kung Fu Yoga in the fourth place, the fifth winner Journey to the West: The Demons Strike Back, and Youth in the eighth place.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
A. O. Scott
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
In eighth place with $6.5 million, Chinese model Liu Wen, 29, is the only Asian model on the list, reflecting the lack of diversity that continues to plague runways.
She’s No. 1: Chancellor Merkel has made the list eight times out of the past ten years — seven times as No. 1.
According to the index, tourists are "spending overwhelmingly" to shop -- and not to dine -- in the top 20 destinations outside of Europe, despite many of them being world-famous cuisine capitals.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
5. Geopolitical flashpoints.In the not too distant past, a small supply disruption would send oil prices skyward. In early 2014, for example, violence in Libya blocked oil exports, contributing to a rise in oil prices. In Iraq, ISIS overran parts of the country and oil prices shot up on fears of supply outages. But since then, geopolitical flashpoints have had much less of an effect on the price of crude. During the last few weeks of 2014, violence flared up again in Libya. But after a brief increase in prices, the markets shrugged off the event. Nevertheless, history has demonstrated time and again that geopolitical crises are some of the most powerful short-term movers of oil prices.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
SETTING: This house is in Kenwood, a neighborhood of 19th- and 20th-century Tudors, Mediterraneans, Victorians and colonial-style houses between Cedar Lake and Lake of the Isles, in the city’s Chain of Lakes. Roads are curving; sidewalks are lined with maple and ash trees. According to the listing agent, many of the neighborhood’s older houses have been restored, while houses built within the last 30 years have been torn down and replaced.
Analysts say headline import figures may start to improve in the coming months since commodity price falls were particularly pronounced at the end of 2014, which will mean smaller year-on-year falls in Chinese imports in value terms.
Build the armed forces through political work and reform, and run them by law
Better still was Iain Roberts, global managing director of the design company Ideo, who asked a question to which I hope never to hear the answer: “How to activate insights around latent mobility or multimodal needs?”
Influenza neuraminidase: A druggable target for natural products
Stevens will perform "Mystery of Love" from the film "Call Me by Your Name," and Bernal, LaFourcade and Miguel will perform "Remember Me" from "Coco."
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
“With the vast number of cutting-edge, eco-friendly faux furs available on the market today, I'm sure you'll agree that there's no longer any excuse for killing animals for their fur.”
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Beauty and Evolution
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Matthew McConaughey and Jared Leto both won for their startlingly gaunt performances in the Texas HIV drama 'Dallas Buyers Club.' Leonardo DiCaprio, a nine-time Golden Globe nominee, won his second Globe for best actor in a comedy for his uninhibited work in 'The Wolf of Wall Street.' He thanked director Martin Scorsese for his mentorship ('Wolf' is their fifth film together) and for 'allowing me to stalk you to make this movie.'
“An employee baked a cake with her resignation letter written on top.”
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
What? Hasn't his firm made enough money off Bernanke's cheap money printing? So he's blaming 'lower growth on fiscal austerity, ' even as Bernanke keeps blowing up the Fed's balance-sheet bubble by trillions under the delusion he's America's savior because our dysfunctional Congress failed?
Inhibition of SARS coronavirus helicase by bismuth complexes
The recovery may help allay some of the gloom around emerging market countries, many of which used strong export growth as a springboard for rapid economic advancement in the early years of this century, before the export boom turned to bust.
US president Donald Trump’s zero-sum, Art-of-the-Deal approach to negotiation will give comfort to old-fashioned incumbents. I am hoping 2018 will provide an opportunity for positive, problem-solving new leaders to emerge. But change could stall if business chiefs, disheartened by the poor quality of political leadership, turn inwards instead.
8. Flats are allowed on the red carpet – or are they?
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
FOYLE’S WAR (acorn.tv, Feb. 2) After nabbing the final three episodes of “Agatha Christie’s Poirot” last year, the streaming service Acorn TV scores another coup in the field of traditional British mysteries with the American premiere of this superior show’s ninth season. Starring Michael Kitchen as Christopher Foyle, a detective as honorable as he is shrewd, the series has morphed over the years from a provincial home-front cop show to a le Carré-like Cold War thriller. New episodes involve the Nuremberg trials and Britain’s role in Palestine.
While a way must be found to aggregate those views, it will always be defective.
The Killing of a Sacred Deer
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Will the BoJ tighten monetary policy
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Best Companies rank: 11
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
With an increase of 7 percent over 2013,total spending on medicines will amount to $1.06trillion in 2014, says the report"The Global Use of Medicines: Outlook through2018" from the IMS Institute for Healthcare Informatics, releasedThursday.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
It shifts your kid's weight to your shoulders and core instead of your back.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
"The average salary level of employees grew by about 6.3 percent year on year in the first three quarters of last year, while China's annual GDP growth stood at 6.7 percent in 2016, both slowing from a year earlier," Jin added.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Dachis says: Adidas added more than 34 million new fans and followers in just 12 months this year. The company put that audience to good use and benefited from high levels of positive discussion all year long.
Season\'s greetings and sincere wishes for a bright and happy New Year!
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Passion, perseverance and a positive attitude tend to set successful entrepreneurs apart. Cultivating these attributes requires an innate skill set and some tips to get started.
New Year should be a time of banked-up fines, the scent of flowers and wine, good talk, good memories and loyalties renewed. But if all else is lacking - love will do.新年是这样美好的时光：炉火熊熊，花儿芬芳，醇酒飘香，殷殷祝福，美好回忆，恩爱日新。即便没有一切，只要有爱便足矣。
中国商务部(Ministry of Commerce)表示，今年1-10月中国对外投资总计863亿美元。
But that idea did not bring Brexit to the UK or Mr Trump to Washington.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
10. China watchers inthe United States will continue to postulate China’s declining growth rate inthe face of evidence that it is stable at over 7%. China will grow fasterin 2014 than in 2013.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Any 'jobs recovery is years away in most cities, ' says USA Today. And in reviewing famed analyst Meredith Whitney's new book, 'The Fate of States, ' she warns that 'excessive pensions crowd out both liberal goals such as education spending and tax cuts that conservatives want.'
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
"Based on experience from previous years, the number of applicants could sharply increase as the application window closes, especially during the last three days of application," an unidentified official with the Ministry of Human Resource and Social Security said on the ministry's website.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
“A worker sent a text to a colleague saying he was quitting and asked her to forward it to management.”
傲人的财务业绩和令人炫目的新科技，或许已足以让这位钢铁般坚定的苹果首席执行官赢得英国《金融时报》2014年年度人物(Person of the Year)的称号。但库克阐述自己价值观的勇气，同样让他与众不同。
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
"Although it may seem counterintuitive, the best way to maximize profits over the long-term is not to make them the primary goal of the business," Mackey said in an interview earlier this year.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Jose's mother Inma Quesada told the El Pais daily that her son "wanted to buy instruments" for his band Los Salerosos (loosely translated as "The Salties"), in which he plays the trumpet.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
具有荷兰和美国双重国籍的Frans de Waal和另一位美国科学家Jennifer Pokorny获得这一奖项，他们的研究确认黑猩猩可以通过辨认同类的屁股照片来认出不同的个体。
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Here, you may be delegates of your governments, business people, organisers, reporters or poiticians - but really you are mothers and fathers, brothers and sister, aunts and uncles - and all of you are somebody's child. 在这里，您可能是您政府商业人士的代表、组织者、记者或政客。但您们也是父亲和母亲、兄弟和姐妹、阿姨和叔叔，你们都会或多或少的为了下一代而活着。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
俄罗斯把自己看作超级大国 -- 这在国内是毋庸置疑的。
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A devastating financial crisis led business owners and corporate executives to be especially wary about adding staff or investing in new equipment. Some worry about risks from Washington or overseas. Others are seeing consumers maintain their slow-but-steady spending, providing little incentive to deploy their cash stockpiles.
It will be interesting to see which direction they go at the trade deadline. They have a handful of solid players along with Brook Lopez.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
9. Occupational therapist
A new paper on the Dutch debacle, coauthored by Peter Koudijs at Stanford Graduate School of Business, turns up modern-day lessons about the not-so-scientific ways in which personal experience rather than market information can determine optimism, pessimism, and access to credit.
Gary Oldman's first film as director in 20 years, and only his second ever, is a biopic of the pioneering 19th-century photographer Eadweard Muybridge, focusing on the affair between his wife, Flora, and Harry Larkyns, the theatre critic he kills. No casting confirmed, but Oldman had been chasing Ralph Fiennes and Benedict Cumberbatch. The man himself will play Muybridge's prosecutor.
The Bellarine Peninsula, located Southwest of Melbourne, Victoria, has been a hotspot for timeless beaches and historic towns like Queenscliff and Portarlington.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
The remains of the monarch -- depicted by William Shakespeare as a monstrous hunchback and often viewed as one of English history's greatest villains -- will now be solemnly reburied in the local cathedral.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
“…brought his dog.”
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Ultimately I expect these new leaders to start selecting from a broader pool of candidates and appoint direct reports from more varied backgrounds, defying those who use current imbalances to extrapolate gloomily that leadership parity between men and women is still decades off.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Recently, a recruitment website issued the Investigation Report of Employability of 2016 Graduates. The report notes that starting salaries for 2016 graduates are 4765 Yuan, nearly 30% graduates to enter the Internet industry which provide the highest average salary.
New Year's greetings and best wishes!
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
The thing about the Mavericks is that this is not at all how Dirk should go out. That team has been so solid his entire career. To have a busted season now is painful. Maybe he ought to have joined Kobe, KG, and Big Fundamental last summer.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
OUTDOOR SPACE: The house is on a fifth of an acre, landscaped by the New York firm Landgarden. The Japanese-style gardens in front make use of native plants. There’s also a back patio and yard, with a second Japanese garden.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
China will continue to improve market environment and tap consumption potential while developing complementary cross-border industrial and value chain with countries along the Belt and Road Initiative in the next five years, according to Gao.
About this collection
"We will set the exact date and location for our operation in consideration of weather conditions, but it will not be publicised," said Park Sang-Hak, a former defector who has led a series of balloon launches
Next year will be the 60th anniversary of the beloved talking bear. And to mark the occasion, Paul King, who directed 2014’s critical and commercial smash, simply titled Paddington, is back for this sequel. In a time where even children’s entertainments are suffused with darkness and violence, this quiet celebration of the everyday English is needed more than ever. The plot of this film? Well, not much really: following the events of the last film, Paddington is quite comfortably installed with the Brown family of Windsor Gardens. He wants to buy a pop-up book for his aunt from a local bookseller, but finding himself a few quid short he puts on his wellies and duffel coat and finds employment in various odd jobs – only to have the book stolen from the shop! A (not so serious) mystery begins. Expect many more jokes about Paddington’s love of marmalade. Released in the UK November 10, November 23 in Germany and November 30 in Cambodia and Malaysia. (Credit: StudioCanal)